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There exists extensive hepatic metabolism, mostly by CYP2B6 and 3A4 isoenzymes; the contribution of CYP2C19 and 2C9 is decrease as opposed with that of CYP2B6Glutamatergic mechanisms of depression are presently the main target of interest following preclinical scientific studies supported the value of this neurotransmission system in the pathogenes… Read More